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Tackling Eyelash Aging! iPS Cell Conditioned Media Paves the Way for New Eyelash Care

2026.05.08
The eyelash serum market has been experiencing explosive growth recently. Tapping into this trend, Shobido has launched the "iPSence Lash Booster," a product formulated with iPS cell conditioned media. We sat down with the developer to discuss the latest trends in eyelash care and this cutting-edge ingredient that's making waves in the beauty world.

PROFILE

Shinya Nakamura

Shobido
Manager, E-commerce Section, Product Planning Department

Just Like Your Hair, Your Eyelashes Age Too

It's common to feel like your hair has lost its body and bounce as you get older. The same is true for your eyelashes. The Shobido brand iPSence has coined the term "eyelash aging" to describe this change.
"As female hormone levels naturally decline with age, hair, including our eyelashes, tends to thin out. In fact, we found that many people in their 40s and beyond become concerned about eyelash loss, with each lash becoming thinner or feeling sparse. An increasing number are worried about their eyes looking less defined."
On top of that, factors like poor nutrient delivery and a disrupted growth cycle can dramatically alter the very environment where lashes grow.
"Plus, with eyelash perms and extensions becoming so common, many people are dealing with accumulated damage. Because of this, we're seeing the market shift away from simply adding volume and toward a focus on 'nurturing' and strengthening the lashes themselves."

What's the Big Deal with the Hot New Ingredient, iPS Cell Conditioned Media?

This is where iPS cell conditioned media comes in, the key ingredient iPSence has zeroed in on.
While iPS cells are a highly anticipated technology in regenerative medicine, this product utilizes the supernatant liquid—the conditioned media—that contains substances secreted during the iPS cell cultivation process. To be clear, it's not the cells themselves, but a solution packed with a diverse array of beneficial components that the cells produce. That's what iPS cell conditioned media is.
iPSence Lash Booster (5g) ¥7,700 (tax included)
"iPS cell conditioned media is packed with beneficial components like growth factors, cytokines, and exosomes, which is why it's increasingly being used in cosmetic medicine, spa treatments, and skincare products."
It's important to be crystal clear with consumers: the product doesn't contain iPS cells themselves, only the beneficial components derived from the conditioned media. Communicating this distinction carefully is crucial to avoid any misunderstanding.
Nakamura explains that the appeal of iPS cell conditioned media isn't just its rich diversity of ingredients, but also its excellent balance of "offensive" and "defensive" properties.
"While it works on the cells that form our skin and hair, over-activation can potentially disrupt the growth cycle or strain the skin. That's why having a formula that balances this is crucial. The beauty of the iPSence Lash Booster is that it strikes this perfect balance."
Another key feature is the inclusion of apple stem cell-derived exosomes, which help protect against daily external stressors like UV rays, dryness, and friction.
"The apple stem cell-derived exosomes are an ingredient derived from a Swiss apple variety called 'Uttwiler Spätlauber.' This apple is known as the 'miracle apple' that doesn't rot for four months, and it has gained attention for its high resistance to external stress. In the beauty field, it's used as a supporting ingredient to help condition the skin's environment."
So, the iPS cell conditioned media supports lash body and resilience, while the apple stem cell-derived exosomes shield them from external damage like UV rays and dryness. In short, the formula is designed to nurture your lashes while protecting them.
A user-friendly package design

Safe by Design: The Evolution of Eyelash Serums

For many, the term 'eyelash serum' still brings to mind the dreaded side effect of hyperpigmentation. This concern stems from older products that used pharmaceutical-derived ingredients like bimatoprost, which could cause skin darkening. Fortunately, the industry has evolved. Nowadays, formulations that nourish lashes without these controversial ingredients are becoming the new standard.
iPSence's Lash Booster tackles this challenge head-on. It skips the ingredients linked to hyperpigmentation and instead harnesses the power of iPS Cell Conditioned Medium. Better yet, its versatile design means you can use it not just on your lashes but also as a treatment for your entire eye area. With its '12-free' and hypoallergenic formula, it’s gentle enough for even the most sensitive skin.
An applicator designed for easy use on eyelids as well.
'UV damage builds up throughout the day, so we specifically designed this product for both morning and evening use. I'm a little lazy myself (laughs), so after applying it to my lashes, I just smooth it over my entire eye area like an eye cream. It’s a fantastic all-in-one for lash and eye care, making it super easy to use. Plus, I love the reassurance that it’s protecting my eye area from environmental stressors during the day.'
The iPSence brand concept, 'Cell-being,' is a portmanteau of 'cell' and 'well-being.'
This Lash Booster is just the first launch from the brand, with plans to expand the lineup with more products featuring iPS Cell Conditioned Medium.
'We don't see "aging care" as simply fighting against the years. For us, it's a proactive approach to unlocking a person's innate potential. Our philosophy is all about enhancing daily life from the cellular level up. We’re excited to continue developing new products with iPS Cell Conditioned Medium based on this idea, so stay tuned!'
iPS Cell Conditioned Medium is already making waves in the beauty industry, particularly in skincare. It's only a matter of time before expectations skyrocket for its potential in the eyelash care space as well.
The focus of eyelash care is shifting from 'enhancing' to 'nurturing.' As this trend continues, a key factor for consumers will be how effortlessly a product can be integrated into their daily routine.

Text by Junko Hayashida

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